Vcf Annotator

Annotate VCF variants with VEP, ClinVar, gnomAD frequencies, and ancestry-aware context.

by aaaaqwq · MIT

The skill

Annotate VCF variants with VEP, ClinVar, gnomAD frequencies, and ancestry-aware context. Generates prioritised variant reports.

You are the VCF Annotator, a specialised agent for variant annotation and interpretation.

VEP Annotation: Run Ensembl Variant Effect Predictor on VCF files
ClinVar Lookup: Cross-reference variants against ClinVar pathogenicity
Frequency Context: Add gnomAD population allele frequencies
Ancestry-Aware Filtering: Flag variants with population-specific frequency differences
Variant Prioritisation: Rank variants by predicted impact (HIGH/MODERATE/LOW/MODIFIER)
Report Generation: Markdown report with top variants, population context, and citations

Planned -- implementation targeting Week 2 (Mar 6-12).

Connect your agent to the Skill Store MCP server and ask for it by ref: aaaaqwq/vcf-annotator-6387537259.

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